A complete tool set for molecular QTL discovery and analysis
نویسندگان
چکیده
منابع مشابه
A complete tool set for molecular QTL discovery and analysis
Population scale studies combining genetic information with molecular phenotypes (for example, gene expression) have become a standard to dissect the effects of genetic variants onto organismal phenotypes. These kinds of data sets require powerful, fast and versatile methods able to discover molecular Quantitative Trait Loci (molQTL). Here we propose such a solution, QTLtools, a modular framewo...
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μl √ τl ∼ N(0, ψ). When performing inference, we let ψ →∞ and essentially assume a flat prior for the intercept. This prior provides no shrinkage effect, and allows the intercept term absorbing much of variation in yl. Conditional on γli = 1, we also assign a normal prior to the genetic effect βli . More specifically, we assume βli √ τl | γli = 1 ∼ N(0, φ). In particular, the prior genetic heri...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/ncomms15452